Article Text

PDF
CD4+ count–guided antiretroviral therapy interruption increased opportunistic disease and death more than continuous therapy in HIV

Statistics from Altmetric.com

J D Lundgren

Dr J D Lundgren, University of Copenhagen, Copenhagen, Denmark; jdl@cphiv.dk

STUDY DESIGN

Design:

randomised controlled trial (RCT) (Strategies for Management of AntiRetroviral Therapy [SMART] study). ClinicalTrials.gov NCT00027352.

Allocation:

{concealed}*.†

Blinding:

{unblinded}‡.†

STUDY QUESTION

Setting:

318 clinical centres in 33 countries.

Patients:

5472 patients {>13 years of age (median age 43 y, 73% men)}‡ who had HIV and CD4+ cell counts >350 cells/µl.

Intervention:

drug conservation (DC), with CD4+ cell count–guided antiretroviral therapy (ART) interruption (ART stopped at counts >350 cells/µl and restarted at counts <250 cells/µl) (n = 2720), or viral suppression (VS) with continuous ART (n = 2752).

Outcomes:

composite of opportunistic disease (OD) or death. Other outcomes included fatal or non-fatal OD, and non-OD death.

Follow-up period:

2 and 4 months, then every 4 months (mean follow-up 16 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.