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Review: postmenopausal hormone therapy increases risk of stroke and venous thromboembolism but not coronary heart disease events

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P M Bath

Dr P M Bath, University of Nottingham, Nottingham, UK; philip.bath@nottingham.ac.uk

QUESTION

What are the effects of hormone therapy (HT) on arterial and venous vascular events in postmenopausal women?

REVIEW SCOPE

Included studies compared risk of vascular events in postmenopausal women receiving HT with that of women receiving placebo or no HT. Outcomes were cerebrovascular disease events (stroke or transient ischaemic attack), coronary heart disease (CHD) events (myocardial infarction, sudden cardiac death, or unstable angina), and venous thromboembolic (VTE) disease events (deep venous thrombosis, pulmonary embolism, or cerebral sinus thrombosis).

REVIEW METHODS

Cochrane Library, Medline, PubMed, and EMBASE/Excerpta Medica (to Jan 2008); and reference lists were searched for randomised controlled trials (RCTs) published in English. 31 trials (n = 44 113, mean age 47–75 y) met the selection criteria. Duration of …

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