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Therapeutics
5-day and 3-day oral prednisolone did not differ for asthma control in children who had acute asthma exacerbations

https://doi.org/10.1136/ebm.14.2.40

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    A B Chang

    Professor A B Chang, Queensland Children's Respiratory Centre, Brisbane, Queensland, Australia; annechang@ausdoctors.net

    STUDY DESIGN

    Design:

    randomised controlled trial. Australian Clinical Trials Registry ACTRN012605000305628.

    Allocation:

    concealed.*

    Blinding:

    blinded (children, parents, and healthcare providers).*

    STUDY QUESTION

    Setting:

    emergency departments (EDs) in 3 hospitals in Queensland, Australia.

    Patients:

    201 children 2–15 years of age (mean age 5 y, 60% boys) who presented to the ED between 7:30 am and 5 pm with acute exacerbation (needing >1 dose of salbutamol in 1 h) of asthma (>2 episodes of wheeze or dyspnoea with decreased respiratory rate and work of breathing in response to salbutamol) and were not admitted to hospital. Exclusion criteria were underlying respiratory disease, cerebral …

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    Footnotes

    • Source of funding: Asthma Foundation of Queensland; Royal Children's Hospital Foundation; Aspen Pharmacare.