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Telmisartan did not prevent recurrent stroke or major cardiovascular events

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S Yusuf

Dr S Yusuf, McMaster University, Hamilton, Ontario, Canada; yusufs@mcmaster.ca

STUDY DESIGN

Design:

randomised placebo-controlled trial with 2 × 2 factorial design (Prevention Regimen for Effectively Avoiding Second Strokes [PRoFESS]). ClinicalTrials.gov NCT00153062.

Allocation concealment:

concealed.*

Blinding:

blinded {patients, clinicians, data collectors, outcome assessors, safety committee, and data analysts}†.*

STUDY QUESTION

Setting:

695 centres in 35 countries worldwide.

Patients:

20 332 …

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