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Review: less than maximum doses of ACE inhibitors lower BP to near maximum levels in hypertension

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B S Heran

Dr B S Heran, University of British Columbia, Vancouver, BC, Canada; bsheran@ti.ubc.ca

QUESTION

In patients with primary hypertension, what is the dose-related efficacy of angiotensin converting enzyme (ACE) inhibitors for lowering blood pressure (BP)?

REVIEW SCOPE

Included studies compared ACE inhibitors with placebo in patients with BP ⩾140/90 mm Hg, measured BP at 3–12 weeks after treatment, and had ⩾3 weeks’ follow-up. Studies of patients taking other drugs affecting BP or having secondary hypertension due to renal failure were excluded. Outcomes included change in trough or peak BP at 3−12 weeks.

REVIEW METHODS

Medline and EMBASE/Excerpta Medica (to February 2007), Cochrane Library (2007, issue 1), and reference lists were searched for double-blind …

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