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Dr A Grant, University of Aberdeen, Aberdeen, UK; email@example.com
randomised controlled trial and economic analysis. Current Controlled Trials ISRCTN15517081.
21 hospitals in the UK.
357 patients ⩾18 years of age (mean age 46 y, 66% men) who had documented evidence of gastro-oesophageal reflux disease (GORD) and symptoms for >12 months and for whom the best management policy was uncertain. Exclusion criteria included body mass index >40 kg/m2, Barrett oesophagus >3 cm, evidence of dysplasia, paraoesophageal hernia, and oesophageal stricture.
a strategy of laparoscopic fundoplication (technique selected by surgeon) (n = 178) or a strategy of best medical management with proton pump inhibitors (PPIs) or histamine-receptor antagonists (n = 179).
primary outcome was …
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