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Influenza immunisation during pregnancy reduced influenza in infants and respiratory illness in mothers

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M C Steinhoff

Dr M C Steinhoff, Cincinnati Children’s Hospital, Cincinnati, OH, USA; m.steinhoff@gmail.com

STUDY DESIGN

Design:

randomised pneumococcal vaccine-controlled trial. ClinicialTrials.gov NCT00142389.

Allocation concealment:

concealed.*

Blinding:

blinded {patients, clinicians, data collectors, outcome assessors, data analysts, and safety committee}†.*

STUDY QUESTION

Setting:

Bangladesh.

Patients:

340 mothers 18–36 years of age (mean age 25 y) in the third trimester of pregnancy. Exclusion criteria were history of systemic disease, previous complicated pregnancy or preterm delivery, abortion, congenital anomaly, or hypersensitivity to study vaccines in the past 3 years.

Intervention:

inactivated influenza vaccine (n = 172) or 23-valent pneumococcal polysaccharide vaccine (n = 168). The influenza vaccine contained strains from 2004 as recommended by the World Health Organization, including A/New Caledonia/20/99 (H1N1), A/Fujian/411/2002 (H3N2), and B/Hong Kong/330/2001.

Outcomes:

included first episode of laboratory-confirmed influenza …

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