Article Text

PDF
Review: D-dimer concentrations predict risk of recurrent VTE after anticoagulant therapy is stopped

Statistics from Altmetric.com

J D Douketis

Dr J D Douketis, St Joseph’s Hospital, Hamilton, Ontario, Canada; jdouket@mcmaster.ca

QUESTION

In patients with unprovoked venous thromboembolism (VTE), do D-dimer concentrations predict risk of recurrent symptomatic VTE after anticoagulant therapy is stopped?

REVIEW SCOPE

Included studies measured D-dimer concentrations at 3 weeks to 2 months after stopping anticoagulant therapy in patients with a first unprovoked VTE who received therapy for ⩾3 months. Outcome was recurrent symptomatic VTE.

REVIEW METHODS

Medline, EMBASE/Excerpta Medica, CINAHL, Cochrane Central Register of Controlled Trials, and reference lists (all to Mar 2008) were searched, and experts were contacted for prospective cohort studies or randomised controlled trials (RCTs). 5 prospective cohort studies and 2 RCTs (n = 1888) met the selection criteria. 4 studies enrolled consecutive patients; all studies used independent outcome assessment blinded to D-dimer results and had …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.