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STUDY DESIGN
Design:
randomized controlled trial. ClinicalTrials.gov NCT00169897; ISRCTN32824512.
Allocation:
concealed.*
Blinding:
blinded {data collectors and analysts, outcome assessors, and safety committee}†.*
STUDY QUESTION
Setting:
10 centres in Canada.
Patients:
252 patients ⩾40 years of age (mean age 66 y, 56% men) who had stable chronic obstructive pulmonary disease (COPD; no change in medication or symptoms for ⩾ 4 wks), were current or former smokers of ⩾10 pack-years, had an FEV1 <70% of predicted value and FEV1–FVC ratio <0.70, and had a Medical Research Council (MRC) dyspnoea score ⩾2. Exclusion criteria included history of asthma, congestive left heart failure as primary disease, terminal disease, dementia, and uncontrolled psychiatric illness.
Intervention:
home-based exercise programme (n = 126) or outpatient, hospital-based exercise programme (n = 126). Both groups received an educational intervention in …
Footnotes
Source of funding: Canadian Institutes of Health Research and Respiratory Health Network of the Fonds de la recherche en santé du Québec.