Article Text

PDF
Oral prednisolone did not improve outcomes in preschool children with an attack of wheezing

Statistics from Altmetric.com

STUDY DESIGN

Design:

randomised placebo-controlled trial. Current Controlled Trials ISRCTN58363576.

Allocation:

concealed.*

Blinding:

blinded (patients, parents, healthcare providers, and outcome assessors).*

STUDY QUESTION

Setting:

3 hospitals in the UK.

Patients:

700 children 10–60 months of age (mean age 26 mo, 64% boys) who presented to hospital with an attack of wheezing associated with a clinically diagnosed upper respiratory viral infection. Exclusion criteria included shock, bacterial sepsis, heart or lung disease, immunodeficiency or immunosuppressive therapy, and varicella infection or recent exposure.

Intervention:

oral prednisolone (10 mg/d if ⩽24 mo of age or 20 mg/d if >24 mo) once daily for 5 days (n = 343) or placebo (n = 344).† All patients received inhaled salbutamol as required and other …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.