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Therapeutics
Oral prednisolone did not improve outcomes in preschool children with an attack of wheezing

https://doi.org/10.1136/ebm.14.3.77

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    STUDY DESIGN

    Design:

    randomised placebo-controlled trial. Current Controlled Trials ISRCTN58363576.

    Allocation:

    concealed.*

    Blinding:

    blinded (patients, parents, healthcare providers, and outcome assessors).*

    STUDY QUESTION

    Setting:

    3 hospitals in the UK.

    Patients:

    700 children 10–60 months of age (mean age 26 mo, 64% boys) who presented to hospital with an attack of wheezing associated with a clinically diagnosed upper respiratory viral infection. Exclusion criteria included shock, bacterial sepsis, heart or lung disease, immunodeficiency or immunosuppressive therapy, and varicella infection or recent exposure.

    Intervention:

    oral prednisolone (10 mg/d if ⩽24 mo of age or 20 mg/d if >24 mo) once daily for 5 days (n = 343) or placebo (n = 344).† All patients received inhaled salbutamol as required and other …

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    Footnotes

    • Source of funding: Asthma UK.