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Review: interferon and nucleoside/tide analogues reduce risk of hepato-cellular cancer in chronic hepatitis B

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QUESTION

Do interferon and nucleoside/tide analogues reduce risk of hepatocellular cancer (HCC) in patients with chronic hepatitis B virus (HBV) infection?

REVIEW SCOPE

Included studies compared interferon, pegylated interferon, or nucleoside/tide analogues (lamivudine, adefovir, entecavir, and telbuvidine) with no antiviral treatment (in any study type) or placebo (in randomised controlled trials [RCTs]) in patients with confirmed chronic HBV infection. Outcome was chronic hepatitis B-related HCC.

REVIEW METHODS

Medline, EMBASE/Excerpta Medica, Cochrane Central Register of Controlled Trials and Database of Abstracts of Reviews of Effects, and International Pharmaceutical Abstracts (all to Nov or Dec 2007); abstracts from major international conferences in the past 10 years; and reference lists were searched for English-language RCTs, case–control studies, or cohort studies. 12 studies (n = 2742) …

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