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Review: long-term annual conversion rate to dementia was 3.3% in elderly people with mild cognitive impairment

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QUESTION

In elderly people with mild cognitive impairment (MCI), what is the long-term rate of conversion to dementia?

REVIEW SCOPE

Included studies examined the progression of MCI, defined according to accepted criteria. Outcomes were dementia or probable Alzheimer disease.

REVIEW METHODS

Medline, EMBASE/Excerpta Medica, and PsycINFO (to Mar 2008) were searched for cohort studies with ⩾5 years of follow-up. 15 studies (n = 2404, mean age 62–82 y) met the selection criteria. Mean follow-up was 6 years (range 5–10 y).

MAIN RESULTS

The cumulative conversion rate to dementia was 31% (15 studies) and to Alzheimer disease was 33% (11 studies). The table shows annual conversion rates. …

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