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Periodic screening with prostate-specific antigen testing reduced mortality from prostate cancer

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STUDY DESIGN

Design:

randomised controlled trial (European Randomised Study of Screening for Prostate Cancer [ERSPC]). Current Controlled Trials ISRCTN49127736.

Allocation:

not concealed, at least in part.* In 3 countries, randomisation occurred before consent was obtained; in the other 4 countries, only consenting participants were randomised, but allocation concealment was unclear.

Blinding:

blinded (outcome adjudication committees).*

STUDY QUESTION

Setting:

7 European countries.

Participants:

162 243 men 55–69 years of age (mean age 61 y). Some countries also enrolled …

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