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Review: intranasal mupirocin ointment reduces Staphylococcus aureus infections in nasal carriersReview: intranasal mupirocin ointment reduces Staphylococcus aureus infections in nasal carriers

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QUESTION

Does mupirocin nasal ointment reduce Staphylococcus aureus infections in patients who are nasal carriers of S aureus?

REVIEW SCOPE

Included studies compared intranasal mupirocin ointment with placebo, no treatment, or an alternative topical treatment in hospital inpatients or outpatients who were nasal carriers of microbiologically confirmed S aureus. Outcomes included S aureus infection, infection caused by other micro-organisms, and mortality.

REVIEW METHODS

Cochrane Wounds Group Specialised Register, CENTRAL, Medline, CINAHL, EMBASE/Excerpta Medica (all to May 2008); System for Information on Grey Literature; Index to Theses (ASLIB Index); mRCT; ClinicalTrials.gov; abstracts from major scientific meetings (1995–2007); and reference lists were searched for published and unpublished randomised controlled trials (RCTs). Researchers, the manufacturer of mupirocin, and …

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