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1 day of nitrofurantoin was not as effective as 7 days for asymptomatic bacteriuria in pregnancyCommentary

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STUDY DESIGN

Design:

randomised controlled trial.

Allocation:

concealed.*

Blinding:

blinded (patients, healthcare providers, data collectors, and outcome assessors).*

STUDY QUESTION

Setting:

antenatal clinics in 7 hospitals in Thailand, the Philippines, Vietnam, and Argentina.

Patients:

778 pregnant women (mean age 27 y) at 12–32 weeks of gestation who were diagnosed (by a 2-step screening process) as having asymptomatic bacteriuria caused by a micro-organism sensitive to nitrofurantoin. Women with symptoms of urinary tract infection (UTI), treatment of UTI in the current pregnancy, a condition requiring continuous steroid or antibiotic therapy, antibiotic hypersensitivity, or haematological disease (including glucose-6-phosphate dehydrogenase deficiency) were excluded.

Intervention:

nitrofurantoin, 100 mg orally twice daily, for 1 day (n = 386) or 7 days (n = 392). The 1-day group received placebo tablets after day 1 to …

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