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Screening for CAD in asymptomatic patients with type 2 diabetes did not reduce risk of cardiac events

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Study design

Design:

randomised controlled trial (Detection of Ischemia in Asymptomatic Diabetics [DIAD]). ClinicalTrials.gov NCT00769275.

Allocation:

concealed.*

Blinding:

blinded (outcome adjudication committee).*

Study question

Setting:

14 centres in the USA and Canada.

Patients:

1123 patients 50–75 years of age (mean age 61 y, 54% men) who had type 2 diabetes diagnosed at ⩾30 years of age, no symptomatic or previously recognised coronary artery disease (CAD), and no history of ketoacidosis.

Intervention:

screening with adenosine-stress radionuclide myocardial perfusion imaging …

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