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Are continuous positive airway pressure (CPAP) devices effective and cost-effective for treatment of obstructive sleep apnoea-hypopnoea syndrome (OSAHS)?
Included studies compared CPAP devices (used for ⩾1 wk) with placebo, supportive or usual care, or dental devices in adults (⩾16 y of age) with OSAHS. Studies in patients with central nervous system dysfunction or heart failure were excluded. Outcomes included subjective daytime sleepiness (Epworth Sleepiness Scale, ESS), ability to stay awake (Maintenance of Wakefulness Test, MWT), blood pressure (BP), and cost-effectiveness.
15 electronic databases including Medline, CINAHL, EMBASE/Excerpta Medica, and Cochrane Central Register of Controlled Trials (to Nov 2006); journals (2005 to May 2007); conference proceedings (2005–6); industry submissions; and the reference list of a previous Cochrane review on the topic were searched for randomised controlled trials (RCTs). 48 RCTs (n = 2521, mean age 44–58 y, 52–100% men) …
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