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Blood pressure–lowering did not improve short-term mortality or dependency in acute stroke and hypertension

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Study design

Design:

randomised placebo controlled trial (Controlling Hypertension and Hypotension Immediately Post Stroke [CHHIPS] study).

Allocation:

concealed.*

Blinding:

blinded (patients and researchers).*

Study question

Setting:

6 centres in England, UK.

Patients:

179 patients >18 years of age with a fixed neurological deficit lasting >60 min, clinical diagnosis of suspected stroke, and symptom onset within 36 hours (depressor group) and hypertension (mean systolic blood pressure [BP] level >160 mm Hg). Exclusion criteria included current antihypertensive therapy in non-dysphagic patients, contraindications to trial therapy, and significant comorbidity or life expectancy <6 months. The pressor group (symptom onset <12 h and hypotension) had only 1 patient, was discontinued, and is not reported here.

Intervention:

lisinopril, 5–15 mg daily (n = 58), labetalol, 50–150 mg on day 1 then 100–300 mg …

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