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Evid Based Med 14:148 doi:10.1136/ebm.14.5.148
  • Therapeutics

Manuka honey improved wound healing in patients with sloughy venous leg ulcers

Study design

Design:

randomised controlled trial.

Allocation:

concealed.*

Blinding:

blinded (statistician).*

Study question

Setting:

vascular centres, leg ulcer clinics, and acute and community care hospitals.

Patients:

108 patients >18 years of age (mean age 68 y) who had a venous leg ulcer (VLU) <100 cm2 with ⩾50% of the wound bed covered in slough. Exclusion criteria were malignant ulcer, wound infection, presence of a cavity wound, use of antibiotics or oral immunosuppressants, poorly controlled diabetes, pregnancy or lactation, and previous enrolment in the study.

Intervention:

Wounds were cleansed with warm tap water and then treated with 5 g/20 cm2 Manuka honey (n = 54), or 3 g/20 cm2 hydrogel therapy (n = 54), weekly for 4 weeks. Use of Allevyn hydrocellular foam as …