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Review: oral vitamin D prevents non-vertebral and hip fractures in a dose-dependent manner in patients ⩾65 years of age

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Question

In patients ⩾65 years of age, does oral vitamin D prevent non-vertebral and hip fractures?

Review scope

Included studies evaluated oral vitamin D supplementation and reported ⩾1 fracture in patients with mean age ⩾65 years; studies had to be double-blind and have ⩾1 year of follow-up. Exclusion criteria included uncontrolled, observational, or animal studies; and studies of patients with organ transplantation or stroke, and those taking steroids or treatment for Parkinson disease. Outcomes were first or repeated non-vertebral fracture or hip fracture.

Review methods

Medline and Cochrane Controlled Trials Register (1960 to Aug 2008), EMBASE/Excerpta Medica (1991 to Aug 2008), reference lists, and abstracts from the American Society of Bone and Mineral Research (1995–2007) were searched, and experts were contacted for randomised controlled trials (RCTs). 12 high-quality RCTs …

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