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Randomised controlled trial
Antipyretic drugs do not reduce recurrences of febrile seizures in children with previous febrile seizure
  1. Andrew L Lux
  1. Dr Andrew L Lux
    Department of Paediatric Neurology, Bristol Royal Hospital for Children, Floor 6, UHBristol Education Centre, Upper Maudlin Street, Bristol BS2 8AE, UK; andrew.lux{at}bristol.ac.uk

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Febrile seizures typically occur between the ages of 6 months and 6 years. They are common, with an estimated cumulative incidence in Europe and North America of 3% to 5%. With “simple” febrile seizures—that is, febrile seizures that have no lateralising features during the attack or afterwards, that last less than 15 min, and that do not recur during a 24 h period—the risk of subsequent epilepsy is probably no different from that in the overall population.

The randomised controlled double-blind study by Strengell and colleagues in five hospitals in Finland investigated the effects of secondary prophylaxis of febrile seizures with antipyretic agents. It enrolled 231 …

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