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Skin and soft tissue infections resulting from Staphylococcus aureus have become an increasing problem in children over the past 15 years largely due to the emergence of community-associated methicillin-resistant S aureus.1 As antibiotic resistance among bacteria has become an increasing problem, strategies to reduce excess use have been explored. This study evaluates whether or not antibiotic therapy in addition to incision and drainage is necessary in the treatment of skin abscesses in children.
Duong and colleagues performed a double-blind randomised, controlled equivalence trial comparing trimethoprim-sulfamethoxazole (TMP-SMX) to placebo in children who had drainage of acute skin abscesses. Children included in the study were between 3 months and 18 years of age who presented without fever, had no co-morbid conditions, were not on immunosuppressive therapy, had no recent or current antibiotic usage and no contraindications for TMP-SMX. Investigators identified 1305 children with acute …
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