Article Text

PDF
Randomised controlled trial
Intensive lowering of systolic blood pressure to a target of less than 120 mm Hg has no effect on the rate of fatal and non-fatal major cardiovascular events in high-risk patients with type 2 diabetes
  1. Atul Chugh1,
  2. George Bakris2
  1. 1Department of Cardiology, University of Louisville Medical Center, Louisville, Kentucky, USA
  2. 2Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
  1. Correspondence to George Bakris
    Pritzker School of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 1027, Chicago, IL 60637, USA; gbakris{at}gmail.com

Statistics from Altmetric.com

Commentary on:

Context

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure recommends a blood pressure (BP) treatment goal of <130/80 mm Hg for patients with diabetes and hypertension.1 This goal was derived from observational data.2 3 The BP arm of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial prospectively addressed whether this lower BP further reduced cardiovascular events in high-risk patients with type 2 diabetes.

Methods

ACCORD was a prospective, open-label, randomised trial that enrolled 10 251 patients at high-cardiovascular risk and type 2 diabetes. Of these, 4733 patients were randomised to either intensive (goal systolic BP (SBP) <120 mm Hg) or standard (goal SBP <140 mm Hg) control in a two-by-two factorial design. High risk was defined as a …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.