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PHYLLIS randomised controlled trial
In hypertensive people treated with an antihypertensive, concomitant statin administration has no additional effect on blood pressure
  1. Abhimanyu Beri,
  2. Tahmeed Contractor
  1. Division of Internal Medicine, Michigan State University, East Lansing, Michigan, USA
  1. Correspondence to Abhimanyu Beri
    B-301 Clinical Center, 138 Service Road, East Lansing, MI 48824, USA; abhiberi{at}gmail.com

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The reduction in major cardiovascular and cerebrovascular events with statins extends beyond their lipid-lowering effects.1 Other pleiotropic benefits have also been ascribed to them,2 including reduction in blood pressure.3 Even small (∼5 mm Hg) decrements in blood pressure can have significant impact on morbidity and mortality. Current literature shows conflicting results regarding the efficacy of statins in controlling hypertension.3 4

The original PHYLLIS trial5 was a double-blinded, multicentre, randomised controlled trial that included 508 men and postmenopausal women with untreated hypertension, hypercholesterolemia and asymptomatic carotid artery atherosclerosis. Subjects were divided …

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