Statistics from Altmetric.com
Initiation of dialysis in patients with chronic kidney disease will depend on a combination of biochemical parameters and/or the development of symptoms and signs of uraemia. Waiting for some of these clinical events may well place the patient in jeopardy. This concern, in addition to a number of cohort studies,1 2 lead to the opinion-based guidelines to initiate chronic dialysis at a predefined, ‘early’ level, based on calculated glomerular filtration rate (GFR).3 The consequence of these recommendations resulted in a doubling, between 1996 and 2005, of patients started on chronic dialysis with an estimated GFR >10 ml/min. The impact of this phenomenon on morbidity and mortality has been debated.4 5 The IDEAL (Initiating Dialysis Early and Late) study was designed to answer this important clinical decision-making dilemma.
This was a prospective, multicentre, randomised …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.