Context

Incidence of acute stroke in older people is continuously growing. However, treatment with intravenous tissue plasminogen activator (tPA) in this group of patients is still scarce.1 The majority of clinical trials using thrombolytic treatment have excluded very older people, and although the last European Stroke Organization (ESO) Guidelines support intravenous tPA treatment without age-limit (class III, level C), the terms of tPA-labelled indications do not include patients ≥80 years.2 The study by Mishra and colleagues aimed to evaluate the safety and efficacy of intravenous tPA according to age, especially in very older people, controlled by patients with similar stroke severity without tPA treatment.