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Systematic review with meta-analysis
Vitamin D supplementation of deficient children may improve bone mineral density
  1. Leticia Manning Ryan
  1. Division of Emergency Medicine, Children's National Medical Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA
  1. Correspondence to Leticia Manning Ryan
    Division of Emergency Medicine, Children's National Medical Center, The George Washington University School of Medicine and Health Sciences, 111 Michigan Avenue, NW, Washington, DC 20010, USA; lryan{at}cnmc.org

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Context

Low bone mineral density has been identified as a risk factor for osteoporotic fracture1 and fracture in childhood.2 Vitamin D supplementation in childhood may be a clinical strategy to maximise peak bone mass in children and, in turn, improve bone mineral density and reduce fracture risk in adulthood. However, the effectiveness of vitamin D supplementation for improving bone density in children is unclear. Therefore, Winzenberg and colleagues performed a systematic review and meta-analysis to evaluate the efficacy of vitamin D supplementation for improving paediatric bone mineral density, including how supplement dose and baseline vitamin D status may impact the outcome.

Methods

This is a systematic review and meta-analysis of studies with the following inclusion criteria: (1) randomised placebo controlled trial …

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