Article Text

PDF
Cohort study
People aged above 65 treated for latent tuberculosis are at increased risk of admission for a hepatic event compared with untreated controls
  1. Philip LoBue
  1. Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  1. Correspondence to Philip LoBue
    Mail Stop E-10, 1600 Clifton Road, Atlanta, GA 30338, USA; plobue{at}cdc.gov

Statistics from Altmetric.com

Commentary on: OpenUrlAbstract/FREE Full Text

Context

Treatment of latent tuberculosis infection (LTBI) is an important tuberculosis prevention and control strategy, especially in high-resource countries. The effectiveness of LTBI treatment, which usually consists of isoniazid (also known as isonicotinylhydrazine (INH)) for 6–9 months, is limited by poor patient adherence because of long treatment duration and adverse effects. The most common serious adverse effect of INH is hepatotoxicity, which increases with age and can be fatal.1 A meta-analysis of six studies found that the pooled rate of INH-associated hepatotoxicity was 0.6%.2

Methods

Smith and colleagues conducted a population-based evaluation of serious adverse events of LTBI treatment in Quebec, Canada. Data were abstracted from administrative databases of the government …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.