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  • In premenopausal women with recurrent UTI, antibiotics were more effective than capsules of cranberry extract for the prevention of UTI, but resistance was higher in the antibiotic group

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Therapeutics
Randomised controlled trial
In premenopausal women with recurrent UTI, antibiotics were more effective than capsules of cranberry extract for the prevention of UTI, but resistance was higher in the antibiotic group
  1. Liza Genao
  1. Center for the Study of Aging and Human Development, Duke University, Durham, North Carolina, USA
  1. Correspondence to Liza Genao
    Center for the Study of Aging and Human Development, Duke University, 201 Trent Drive, Box 3003, Durham, NC 27710, USA; liza.genao{at}duke.edu

https://doi.org/10.1136/ebm.2011.100231

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    Commentary on: Beerepoot MA, ter Riet G, Nys S, et al. Cranberries vs antibiotics to prevent urinary tract infections: a randomized double-blind noninferiority trial in premenopausal women. Arch Intern Med 2011;171:1270–8.OpenUrlCrossRefPubMedWeb of Science

    Context

    Clinical recurrence (CR) of urinary tract infection (UTI) is common in premenopausal women. Practice guidelines recommend 6–12 months of prophylactic antibiotics for CR of UTI. A meta-analysis demonstrated that prophylaxis with antibiotics was 85% (RR 0.15, (0.08 to 0.28)) better than placebo in pre and postmenopausal women. However, antibiotics cause adverse effects (AEs) (RR 1.58 (0.47 to 5.28)) and antimicrobial resistance1 prompting great interest in safer prophylaxis options. In a meta-analysis of two randomised control trials, cranberries were 39% (RR 0.61, (0.40 to 0.91)) better than placebo in preventing CR of UTI in premenopausal women without causing severe AEs.2 In postmenopausal women, antibiotics were similar to cranberries in reducing CR of UTI.3 Beerepoot et al aimed to demonstrate that …

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    Footnotes

    • Competing interests None.