Evid Based Med 17:188-189 doi:10.1136/ebmed-2012-100780
  • Therapeutics

Forty-month trial suggests repeated hyaluronic acid injections for people with knee osteoarthritis may act as a long-term slow acting drug

  1. Xavier Chevalier
  1. Correspondence to Xavier Chevalier
    Department of Rheumatology, Hopital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, Creteil 94010, France; Xavier.Chevalier{at}

Commentary on:


Hyaluronic acid (HA) injections are recommended in the management of knee osteoarthritis (OA) by international societies because of their long-term effect.1 ,2


AMELIA is the longest (3 years) randomised, placebo controlled trial in patients with symptomatic knee OA. Eligible patients were men and women (>45 years) with knee OA and pain of 55 mm or greater on a visual analogue scale. Participants were given four cycles of five weekly intra- articular injections of HA (2.5 ml 1% sodium hyaluronate) or placebo (2.5 ml of saline solution). Follow-up was conducted at …

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBM.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article