You are here

  • Home
  • Archive
  • Volume 17, Issue 6
  • Forty-month trial suggests repeated hyaluronic acid injections for people with knee osteoarthritis may act as a long-term slow acting drug

Article Text

Article menu
Download PDFPDF
Therapeutics
Forty-month trial suggests repeated hyaluronic acid injections for people with knee osteoarthritis may act as a long-term slow acting drug
  1. Xavier Chevalier
  1. Correspondence to Xavier Chevalier
    Department of Rheumatology, Hopital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, Creteil 94010, France; Xavier.Chevalier{at}hmn.aphp.fr

https://doi.org/10.1136/ebmed-2012-100780

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Commentary on: Navarro-Sarabia F, Coronel P, Collantes E, et al. A 40-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project. Ann Rheum Dis 2011;70:1957–62.OpenUrlAbstract/FREE Full Text

    Context

    Hyaluronic acid (HA) injections are recommended in the management of knee osteoarthritis (OA) by international societies because of their long-term effect.1 ,2

    Methods

    AMELIA is the longest (3 years) randomised, placebo controlled trial in patients with symptomatic knee OA. Eligible patients were men and women (>45 years) with knee OA and pain of 55 mm or greater on a visual analogue scale. Participants were given four cycles of five weekly intra- articular injections of HA (2.5 ml 1% sodium hyaluronate) or placebo (2.5 ml of saline solution). Follow-up was conducted at …

    View Full Text

    Footnotes

    • Competing interests None.