Evid Based Med 18:25 doi:10.1136/ebmed-2012-100691
  • Therapeutics
  • Randomised controlled trial

A 10-day course of amoxicillin does not reduce symptoms of acute rhinosinusitis at day 3 of treatment

  1. Michael R Jacobs3
  1. 1University of Pittsburgh School of Medicine Department of Otolaryngology, Pennsylvania, USA
  2. 2University of Pittsburgh School of Medicine, Department of Otolaryngology, Pittsburgh, Pennsylvania, USA
  3. 3Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
  1. Correspondence to: Jack Anon
    University Pittsburgh School of Medicine, 580 Peach St, Erie, Pittsburgh, Pennsylvania, USA; jack{at}

Commentary on: .


Despite the controversy regarding their clinical benefit and concerns about resistance, the use of antimicrobials for rhinosinusitis (RS) accounts for one in five prescriptions for adults in the USA. However, we lack a simple diagnostic or predictive tool for determining whether acute viral RS has progressed to secondary bacterial RS, and must therefore rely on a patient's history and limited physical findings to diagnose RS. Using guidelines recommended by a small expert panel and partially funded by the US Centers for Disease Control and Prevention, this study attempts to answer the question of whether amoxicillin is an effective treatment for acute RS?


This was a randomised, blinded, placebo-controlled, multi-centre study undertaken between …

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