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Evid Based Med 18:32-33 doi:10.1136/eb-2012-100762
  • Therapeutics
  • Randomised controlled trial

Antibiotics may not improve short-term or long-term outcomes in acute uncomplicated diverticulitis

  1. Tim W Eglinton2
  1. 1Department of Surgery, Christchurch Hospital, Christchurch, New Zealand
  2. 2Department of Surgery, University of Otago, Christchurch, New Zealand
  1. Correspondence to: Tim W Eglinton
    Department of Surgery, University of Otago, Christchurch 8140, New Zealand; tim.eglinton{at}cdhb.govt.nz

Commentary on:

Context

Diverticular disease affects one in three people over the age of 60 years in Western countries and up to a quarter of these patients will develop diverticulitis.1 ,2 Acute uncomplicated diverticulitis typically presents with localised abdominal pain, fever and raised inflammatory markers. The current standard of care is antibiotic treatment, although evidence supporting this recommendation is lacking.1 This study evaluates whether or not antibiotic therapy for acute uncomplicated left-sided diverticulitis improves recovery.

Methods

A non-blinded randomised clinical trial comparing treatment of acute uncomplicated left-sided diverticulitis with or without antibiotics was performed. Adult patients were enrolled if …

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