Evid Based Med 18:37-38 doi:10.1136/ebmed-2012-100651
  • Aetiology
  • Systematic review

Children surviving intrauterine and neonatal insults have a significant risk of long-term adverse neurodevelopmental outcomes

  1. Shripada C Rao1,2,3
  1. 1Department of Neonatal paediatrics, KEM Hospital for Women, Perth, Australia
  2. 2Department of Neonatal Paediatrics, Princess Margaret Hospital for Children, Perth, Australia
  3. 3Centre for Neonatal Research and Education, University of Western Australia, Perth, Australia
  1. Correspondence to: Sanjay Patole
    Department of Neonatal Paediatrics, KEM Hospital for Women, 374, Bagot Road, Subiaco, Perth, WA 6008, Australia; sanjay.patole{at}

Commentary on:


Children who survive intrauterine and neonatal insults are known to be at risk for long-term adverse neurodevelopmental outcomes. However, the extent to which this occurs, especially in resource-poor nations, is not well documented. The systematic review by Mwaniki et al focuses on this important issue.


The authors searched Medline, CINAHL, EMBASE and the Cochrane Library for studies until June 2011 with no language restrictions. Unpublished studies and grey literature were searched using Dissertation Abstracts International and the WHO library. Reference lists of identified reports were searched for additional …

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