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Evid Based Med 18:42 doi:10.1136/ebmed-2012-100792
  • Diagnosis
  • Cohort study

High-sensitivity troponin useful for diagnosis and prognosis in patients with acute coronary syndrome

  1. Alessia Agresta
  1. Department of Cardiology, Centro Polidiagnostico Stabile, Salerno, Italy
  1. Correspondence to : Eugenio Stabile
    Department of Cardiology, Centro Polidiagnostico Stabile, via diaz 32, Salerno 84100, Italy; geko50{at}hotmail.com

Context

High-sensitivity cardiac troponin (hs-cTnT) determination has improved cTnT evaluation in patients with acute coronary syndrome (ACS). The hs-cTnT ‘normal value’ is considered to be <99th percentile (0.014 ug/l). Hs-cTnT can diagnose an acute myocardial infarction (AMI) earlier than common cTnT determinations, even in patients with previous CAD.1 ,2 Some studies have shown higher specificity of hs-cTnT in AMI diagnosis, compared with common cTnT determinations.3 Hs-cTnT is also a better predictor of death and heart failure in patients with chest pain and ACS during follow-up.1 ,2 ,4

Methods

The APACE study, a multicentre prospective trial, enrolled a total of 1181 consecutive patients who were admitted to the emergency department because of chest …

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