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Systematic review with meta-analysis
Metformin may not reduce cardiovascular risk or all-cause mortality
  1. Matteo Monami
  1. Correspondence to: Matteo Monami
    Department of Cardiovascular Medicine, Section of Diabetes, Cardiovascular and Geriatric Medicine, University of Florence and Careggi Teaching Hospital, Via delle Oblate 4, Florence 50141, Italy; mmonami{at}libero.it

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The treatment of hyperglycaemia is considered as one of the tools for preventing cardiovascular disease in Type 1 and Type 2 diabetic (T2D) patients.1 ,2 Metformin is recommended as the first-line drug for T2D by most international guidelines (IDF.2005. http://www.idf.org, 2007. http://www.aace.com, http://www.diabetesjournals.org, http://www.nice.org.uk/CG66). The preference for metformin over other available drugs is based on its efficacy on blood glucose control, tolerability, safety and low cost (IDF.2005. http://www.idf.org, 2007. http://www.aace.com, http://www.diabetesjournals.org, http://www.nice.org.uk/CG66). Metformin seems to have a favourable profile of action on several extraglycaemic risk factors, including lipids, …

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