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Systematic review
Lung cancer screening with low-dose CT: benefits and potential risks
  1. Nichole T Tanner,
  2. Gerard A Silvestri
  1. Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, 96 Jonathan Lucas Street, CSB Suite 812, Charleston, SC 29425, USA
  1. Correspondence to : Dr Nichole T Tanner
    Medical Univestity of South Carolina, Charleston, SC 29425, USA; tripici{at}musc.edu

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Context

Lung cancer is the leading cause of cancer death worldwide.1 The majority of patients present with advanced disease and the current 5-year survival is only 15%.2 Previous research showed no mortality benefit to screening with chest radiography and sputum cytology. The recent results of the National Lung Screening Trial (NLST) are the first to show a significant reduction in lung cancer mortality with the use of low-dose CT (LDCT) in high risk individuals. The potential for harm with screening and generalisability of results have been a cause for concern in initiation of lung cancer screening programmes. As such, a multisociety collaborative initiative was undertaken to develop the foundation for a clinical guideline for lung cancer screening.

Methods

The authors performed a literature search using MEDLINE, EMBASE and the Cochrane Library databases …

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