Evid Based Med 18:108-109 doi:10.1136/eb-2012-100926
  • Prevention
  • Systematic review

Lung cancer screening with low-dose CT: benefits and potential risks

  1. Gerard A Silvestri
  1. Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, 96 Jonathan Lucas Street, CSB Suite 812, Charleston, SC 29425, USA
  1. Correspondence to : Dr Nichole T Tanner
    Medical Univestity of South Carolina, Charleston, SC 29425, USA; tripici{at}

Commentary on:


Lung cancer is the leading cause of cancer death worldwide.1 The majority of patients present with advanced disease and the current 5-year survival is only 15%.2 Previous research showed no mortality benefit to screening with chest radiography and sputum cytology. The recent results of the National Lung Screening Trial (NLST) are the first to show a significant reduction in lung cancer mortality with the use of low-dose CT (LDCT) in high risk individuals. The potential for harm with screening and generalisability of results have been a cause for concern in initiation of lung cancer screening programmes. As such, a multisociety collaborative initiative was undertaken to develop the foundation for a clinical guideline for lung cancer screening.


The authors performed a literature search using MEDLINE, EMBASE and the Cochrane Library databases …

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBM.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article