Evid Based Med 18:112-113 doi:10.1136/eb-2012-100912
  • Prognosis
  • Cohort study

Appointment and medication non-adherence is associated with increased mortality in insulin-treated type 2 diabetes

  1. Ildiko Lingvay
  1. Department of Internal Medicine, Division of Endocrinology, UT Southwestern Medical Center, Dallas, TX, USA
  1. Correspondence to
    Dr Ildiko Lingvay, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8857, USA; ildiko.lingvay{at}

Commentary on:


Diabetes increases the risk of death twofold; identifying novel modifiable risk factors could improve patient outcomes and focus healthcare spending in areas with the highest return. Non-adherence to prescribed medications and clinic appointments may be independent risk factors for excess mortality.


Currie and colleagues performed a database review of insulin-treated patients with type 2 diabetes who followed up for 6 months prior to insulin initiation and at least 30 months post-insulin initiation during which compliance with any medications and appointments were evaluated. Mortality was assessed from the end of 36 months (index date) which fell between 2000 and 2009. Information from 15 984 charts was collected until death or …

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