Evid Based Med 18:e22 doi:10.1136/eb-2012-100925
  • Therapeutics
  • Randomised controlled trial

Zinc supplementation for probable serious bacterial infection in early infancy may reduce the need for antibiotic change

  1. Charles P Larson
  1. Centre for International Child Health, British Columbia Children's Hospital, Vancouver, British Columbia, Canada
  1. Correspondence to: Dr Charles P Larson
    Centre for International Child Health, British Columbia Children's Hospital, K4–104, 4800 Oak, Vancouver, British Columbia V6H 3V4, Canada; clarson{at}

Commentary on:


It has now been over 15 years since the publication of the landmark study by Sazawal et al1 demonstrating the efficacy of zinc supplementation during an acute diarrheal episode in children under 5. Since then, dozens of clinical trials have been undertaken to further unravel the role of zinc supplementation to reduce under-5 morbidity and mortality. It is widely accepted that in zinc-deficient populations, zinc supplementation has both curative and preventive effects in the management of acute or chronic childhood diarrhoea with the potential to significantly reduce under-5 mortality.2 While systematic reviews have concluded zinc has no impact on childhood …

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