Evid Based Med 18:e26 doi:10.1136/eb-2012-100971
  • Diagnosis
  • Systematic review and meta-analysis

Confirming the value of pulse oximetry screening for diagnosing critical congenital heart disease

  1. Julien I E Hoffman
  1. Department of Pediatrics, University of California, San Francisco, California, USA
  1. Correspondence to : Dr Julien I E Hoffman
    925 Tiburon Boulevard, Tiburon, CA 94920-1525, USA; julien.hoffman{at}

Commentary on:


Thangaratinam and colleagues, studied the value of pulse oximetry screening of neonates for critical congenital heart disease (CCHD). CCHD is usually defined as a congenital heart disease (CHD) that requires treatment in the neonatal period to prevent death or severe morbidity; most of these neonates have ductus-dependent lesions. About 25–40% of children born with CHD have CCHD, and 10–35% of these infants leave hospital undiagnosed. Some die at home, and others return to hospital critically ill, with resulting higher operative mortality and morbidity, increased hospital costs and suboptimal outcomes.

Pulse oximetry has been recommended to decrease these missed diagnoses, …

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