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Systematic review with meta-analysis
Meta-analysing randomised controlled trials with omega-3 fatty acids in cardiovascular disease
  1. Clemens von Schacky
  1. Department of Preventive Cardiology, University of Munich, Munich, Germany
  1. Correspondence to : Clemens von Schacky
    Department of Preventive Cardiology, University of Munich, Ziemssenstr. 1 Munich 80336, Germany; Clemens.vonschacky{at}med.uni-muenchen.de

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Context

Systematic reviews and meta-analyses have yielded conflicting results regarding the efficacy of ω-3 fatty acids for preventing cardiovascular events or reducing mortality.1 A meta-analysis of randomised, double-blind, placebo-controlled trials now adds to the literature.

Methods

Medline and bibliographies of publications were searched with pertinent keywords, and publications were selected, if trial participants were >18 years of age, had a history of coronary artery disease, used omega-3 fatty acid supplements for >1 year; and if the study design was randomised, double-blind, placebo-controlled, and the trial reported major adverse events …

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