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Randomised controlled trial
Lower target oxygen saturation levels in preterm infants are associated with increased mortality and decreased rates of retinopathy of prematurity
  1. Daniele Trevisanuto,
  2. Veronica Mardegan
  1. Children's and Women's Health Department, University of Padua, Azienda Ospedaliera di Padova, Padova, Italy
  1. Correspondence to: Dr Daniele Trevisanuto, Children's and Women's Health Department, University of Padua, Azienda Ospedaliera Padova, Via Giustiniani, 3 Padova, 35128, Italy; trevo{at}pediatria.unipd.it

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Context

The goal of oxygen therapy is to deliver sufficient oxygen to the tissues while minimising oxygen toxicity and oxidative stress. Although many extremely preterm infants receive supplemental oxygen for prolonged periods, the optimal oxygen saturation has not yet been defined.

Methods

The Benefits Of Oxygen Saturation Targeting (BOOST) II randomised controlled trial (RCT) aimed to evaluate the effects of targeting an oxygen saturation of 85–89%, as compared with a range of 91–95%, on disability-free survival at 2 years in infants born before 28 weeks’ gestation. During the study period, two major changes were made to the original study protocol; first, in the midst of the UK and Australian trials, …

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