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Cohort study
High-potency statins are associated with increased hospitalisations with acute kidney injury
  1. Daniel O Keys,
  2. Charles L Edelstein
  1. University of Colorado Denver, Aurora, Colorado, USA
  1. Correspondence to : Professor Charles L Edelstein, University of Colorado Denver, 12700 East 19th Avenue, Renal Box C 281, Aurora, CO 80045, USA; charles.edelstein{at}ucdenver.edu

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Context

Statins are commonly used medications for the reduction of low-density lipoprotein cholesterol resulting in markedly improved cardiovascular disease outcomes.1 Prior studies with regard to acute kidney injury (AKI) risk in statin users versus non-statin users show mixed results. Dormuth and colleagues address the question of whether high-potency statin therapy is associated with increased hospitalisation for AKI compared to low-potency statin therapy, thereby decreasing indication bias for statin use as a confounder.

Methods

The Canadian Network for Observational Drug Effect Studies (CNODES) are an observational retrospective database meta-analysis of 2 008 003 patients without chronic kidney disease …

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