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Randomised controlled trial
For proton pump inhibitor-dependent gastro-oesophageal reflux, laparoscopic fundoplication is superior to medical therapy at 5 years of follow-up
  1. David I Watson,
  2. Tim Bright
  1. Flinders University Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia
  1. Correspondence to : Professor David Watson, Flinders University Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia, 5042, Australia; david.watson{at}flinders.edu.au

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Context

Gastro-oesophageal reflux disease (GORD) is common in western countries. Up to 40% experience symptoms at least once a month and 10% of adults use proton pump inhibitor (PPI) medication for GORD.1 The REFLUX study addresses a question fundamental to the management of this problem: what is the best treatment strategy? The current study reports 5-year outcomes of a multicentre randomised clinical trial of surgery versus medical management in the UK.

Methods

This randomised controlled trial (RCT) included individuals with objective evidence of GORD who had undergone PPI treatment with reasonable control of GORD symptoms for at least 12 months whom the …

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