Article Text

PDF
Systematic review and meta-analysis
Inconclusive evidence about the efficacy of diverse strategies for intermittent versus daily inhaled corticosteroids for persistent asthma in adults and children
  1. Helen K Reddel,
  2. Juliet M Foster
  1. Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia
  1. Correspondence to Associate Professor Helen K Reddel
    Clinical Management Group, Woolcock Institute of Medical Research, 431 Glebe Point Road, Glebe, NSW 2037, Australia; helen.reddel{at}sydney.edu.au

Statistics from Altmetric.com

Commentary on:

Context

Although inhaled corticosteroids (ICS) are remarkably effective for improving asthma control and reducing mortality, many patients avoid regular use, often stopping treatment when symptoms improve.1 There is increasing interest in investigating ICS regimens which do not require daily treatment.

Methods

The aim of this review was to evaluate parallel group trials comparing daily ICS with ‘intermittent’ ICS in persistent asthma, with ‘intermittent’ defined as ICS initiated ‘at the onset of exacerbations and continued for a short duration’. Studies were identified from the Cochrane Airways Group specialised register of trials, together with hand-searching. The search terms included: intermittent, as-needed, prn (prescribed-as-needed), occasional and short course; these emerged as having highly variable meanings. Eligible patients were adults and children with persistent asthma (undefined) and preschool children at risk of, or with suspected, asthma. Combination ICS/short-acting β2-agonist (SABA) was permitted but not ICS/long-acting …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.