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Cohort study
Long-term aspirin use and neovascular age-related macular degeneration: association or causation?
  1. William G Christen
  1. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
  1. Correspondence to : Dr William G Christen
    Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, 3rd floor, Boston, MA 02215, USA; wchristen{at}rics.bwh.harvard.edu

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Context

Aspirin is used by many for temporary pain relief, rheumatological conditions and where indicated, cardioprotection. However, recent findings from observational studies have raised the possibility that regular aspirin use may also increase the risk of some forms of age-related macular degeneration (AMD).

Methods

Liew and colleagues examined the relationship between long-term, low-dose aspirin use and risk of AMD in an Australian population-based cohort of 2389 adult men and women. Retinal photographs were obtained at baseline and at 5-year intervals over a 15-year follow-up period, and the AMD status was determined using an international AMD classification system. Participants completed a questionnaire at baseline providing information on a range of risk factors for AMD. Use of aspirin and other medications was ascertained during a structured interview administered at baseline using a standard questionnaire. …

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