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Systematic review and meta-analysis
Central venous catheters coated or impregnated with antimicrobial agents effectively prevent microbial colonisation and catheter-related bloodstream infections
  1. Mark E Rupp
  1. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
  1. Correspondence to : Dr Mark E Rupp, Department of Internal Medicine, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198, USA; merupp{at}unmc.edu

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Context

A total of 78 000 catheter-related bloodstream infections (CRBSI) occur in US hospitals and dialysis units annually, resulting in a mortality rate of 12.3% and an excess cost of US$7288–US$29 156/case. A commonly used and guideline-supported strategy to prevent CRBSI is to use a central venous catheter (CVC) that has been impregnated with antimicrobial agents.

Methods

Lai and colleagues performed a systematic review of randomised controlled trials (RCTs) that studied any type of coated CVC compared with either a non-coated CVC or CVC with another coating. The major outcomes of interest were clinically diagnosed sepsis, CRBSI and mortality. A comprehensive search strategy was used. The Cochrane data extraction method was utilised with two reviewers independently evaluating study relevance and risk of bias. …

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