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A total of 78 000 catheter-related bloodstream infections (CRBSI) occur in US hospitals and dialysis units annually, resulting in a mortality rate of 12.3% and an excess cost of US$7288–US$29 156/case. A commonly used and guideline-supported strategy to prevent CRBSI is to use a central venous catheter (CVC) that has been impregnated with antimicrobial agents.
Lai and colleagues performed a systematic review of randomised controlled trials (RCTs) that studied any type of coated CVC compared with either a non-coated CVC or CVC with another coating. The major outcomes of interest were clinically diagnosed sepsis, CRBSI and mortality. A comprehensive search strategy was used. The Cochrane data extraction method was utilised with two reviewers independently evaluating study relevance and risk of bias. …
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