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Central venous pressure (CVP) has been extensively studied in relation to preload and preload responsiveness. In 2008 Marik et al 1 showed the inability of CVP and Δ-CVP to evaluate blood volume status and predict fluid-responsiveness in a systematic review and meta-analysis of 24 studies. In spite of that level of evidence, surviving sepsis campaign guidelines still recommend targeting CVP in order to guide fluid therapy in severe sepsis and septic shock. Interestingly, in Rivers’ study,2 one of the studies referenced to use CVP, the same CVP target values were used in the control as well as …
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