rss
Evid Based Med 19:67 doi:10.1136/eb-2013-101566
  • Therapeutics
  • Randomised controlled trial

An interferon-free, all-oral regimen is effective in treatment of genotype 1 chronic HCV infection

  1. Andrew W Tai
  1. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
  1. Correspondence to: Dr Andrew W Tai, Department of Internal Medicine, University of Michigan, 6520 MSRB I SPC 5682 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA; andrewwt{at}med.umich.edu

Commentary on:

Context

The current standard-of-care therapy for patients with chronic genotype 1 hepatitis C virus (HCV) infection is a combination of peginterferon, ribavirin and a direct-acting antiviral (DAA) NS3/4A protease inhibitor (telaprevir or boceprevir).1 While this regimen is associated with sustained virological response (SVR) rates of approximately 67–75% among treatment-naïve patients, they are substantially lower in ‘difficult-to-treat’ populations including black patients, those with cirrhosis, and treatment-experienced patients. Furthermore, these medications, particularly peginterferon, are associated with substantial side effects that can limit treatment or preclude therapy initiation. The development of additional DAA classes that target the NS5B RNA polymerase and the NS5A protein opens the door to highly effective and potentially better tolerated interferon-free regimens.

Methods

Zeuzem and colleagues conducted a multicentre, randomised, open-label, phase …

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBM.
View free sample issue >>


Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article